John F Paolini Selected Research

rilonacept

1/2021	Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis. Reply.
1/2021	Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis.
1/2021	Health-related quality of life in patients with recurrent pericarditis: results from a phase 2 study of rilonacept.
11/2020	Efficacy and safety of rilonacept for recurrent pericarditis: results from a phase II clinical trial.
10/2020	RHAPSODY: Rationale for and design of a pivotal Phase 3 trial to assess efficacy and safety of rilonacept, an interleukin-1α and interleukin-1β trap, in patients with recurrent pericarditis.

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John F Paolini Research Topics

Disease

11	Flushing 08/2012 - 07/2007
8	Inflammation (Inflammations) 01/2022 - 01/2014
7	Pericarditis 10/2021 - 10/2020
7	Atrial Fibrillation 07/2014 - 09/2011
7	Stroke (Strokes) 07/2014 - 09/2011
7	Dyslipidemias (Dyslipidemia) 03/2010 - 09/2004
6	Embolism (Embolus) 07/2014 - 09/2011
5	Hemorrhage 07/2014 - 09/2011
4	Cardiovascular Diseases (Cardiovascular Disease) 05/2015 - 01/2009
3	Pain (Aches) 01/2021 - 10/2020
3	Atherosclerotic Plaque (Atheroma) 06/2017 - 12/2014
3	Atherosclerosis 06/2017 - 01/2014
2	Vascular System Injuries 01/2022 - 01/2003
2	Giant Cell Arteritis (Horton Disease) 01/2022 - 01/2022
2	Pneumonia (Pneumonitis) 06/2021 - 08/2020
2	COVID-19 06/2021 - 08/2020
2	Acute Coronary Syndrome 06/2017 - 12/2014
2	Coronary Artery Disease (Coronary Atherosclerosis) 06/2017 - 12/2014
2	Rare Diseases (Rare Disease) 05/2015 - 03/2015
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 05/2014 - 09/2011
2	Transient Ischemic Attack 05/2014 - 03/2014
2	Hypercholesterolemia 05/2009 - 01/2009
2	Pruritus (Itching) 04/2009 - 07/2007
1	Necrosis 01/2022
1	Respiratory Insufficiency (Respiratory Failure) 06/2021
1	Prurigo 01/2021
1	Injection Site Reaction 01/2021
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2021
1	Constrictive Pericarditis 12/2020
1	Cardiac Tamponade 12/2020
1	Fever (Fevers) 08/2020
1	Homozygous Familial Hypercholesterolemia 05/2015
1	Hypoalphalipoproteinemias (Hypoalphalipoproteinemia) 03/2015
1	Hemorrhagic Stroke 07/2014
1	Heart Failure 05/2014
1	Chronic Obstructive Pulmonary Disease (COPD) 03/2014
1	Anemia 03/2014
1	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2014
1	Ischemic Stroke 09/2011
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2010
1	Hyperlipidemias (Hyperlipidemia) 05/2009

Drug/Important Bio-Agent (IBA)

12	Niacin (Nicotinic Acid)FDA LinkGeneric 08/2012 - 07/2007
9	MK-0524IBA 11/2010 - 03/2008
8	LipidsIBA 01/2014 - 10/2008
7	RivaroxabanIBA 07/2014 - 09/2011
6	CER-001IBA 06/2017 - 01/2014
6	Warfarin (Coumadin)FDA LinkGeneric 07/2014 - 09/2011
5	C-Reactive ProteinIBA 06/2021 - 10/2020
5	rilonacept FDA Link 01/2021 - 10/2020
5	ProstaglandinsIBA 08/2012 - 03/2008
4	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2022 - 08/2020
4	mavrilimumabIBA 01/2022 - 08/2020
4	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 03/2014 - 11/2007
3	CytokinesIBA 01/2022 - 01/2021
3	HDL LipoproteinsIBA 06/2017 - 12/2014
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2015 - 01/2009
3	CholesterolIBA 03/2015 - 01/2014
3	Vitamin K FDA Link 07/2014 - 03/2014
3	Factor Xa (Coagulation Factor Xa)IBA 07/2014 - 03/2014
3	TabletsIBA 05/2009 - 11/2008
2	Granulocyte-Macrophage Colony-Stimulating Factor Receptors (GM-CSF Receptor)IBA 01/2022 - 06/2021
2	Monoclonal AntibodiesIBA 06/2021 - 08/2020
2	Colchicine FDA LinkGeneric 02/2021 - 10/2020
2	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2020 - 10/2020
2	LDL CholesterolIBA 05/2015 - 10/2008
2	Apolipoprotein A-I (Apolipoprotein A1)IBA 05/2015 - 01/2015
2	Lipoproteins (Lipoprotein)IBA 03/2015 - 07/2009
2	CreatinineIBA 07/2014 - 03/2014
2	Factor Xa InhibitorsIBA 07/2014 - 10/2011
2	Prostaglandin D2IBA 04/2009 - 11/2008
2	prostaglandin D2 receptorIBA 04/2009 - 11/2008
1	Interleukin-6 (Interleukin 6)IBA 01/2022
1	Prednisone (Sone)FDA LinkGeneric 01/2022
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2022
1	HLA-DR Antigens (HLA-DR)IBA 01/2022
1	Metalloproteases (Metalloproteinases)IBA 01/2022
1	InterferonsIBA 01/2022
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2022
1	InflammasomesIBA 02/2021
1	ZymosanIBA 02/2021
1	Oncostatin MIBA 01/2021
1	Oncostatin M Receptor beta SubunitIBA 01/2021
1	Interleukin-1 (Interleukin 1)IBA 01/2021
1	oxidized low density lipoproteinIBA 05/2015
1	LDL Lipoproteins (beta Lipoproteins)IBA 05/2015
1	SterolsIBA 03/2015
1	ATP Binding Cassette Transporter 1IBA 01/2015
1	Adenosine Triphosphate (ATP)IBA 01/2015
1	Apolipoproteins E (ApoE)IBA 01/2015
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2015
1	Messenger RNA (mRNA)IBA 01/2015
1	Serum AlbuminIBA 05/2014
1	LDL Receptors (LDL Receptor)IBA 01/2014
1	Prostaglandins DIBA 05/2009
1	HDL CholesterolIBA 10/2008
1	Nonesterified Fatty Acids (NEFA)IBA 10/2008

Therapy/Procedure

8	Therapeutics 01/2022 - 11/2007
1	Episode of Care 10/2021
1	Immunomodulation 01/2021
1	Artificial Respiration (Mechanical Ventilation) 08/2020